Seasonal flu killed 830 children from 2004 to 2012, and 43 percent of them had no high-risk medical conditions. The rest of the children had neurological, pulmonary, cardiac and other serious disorders.
A new report, published in Pediatrics, used data from the Centers for Disease Control and Prevention on laboratory-confirmed cases of influenza in children under 18.
Recommendations for vaccination changed over the period, but since 2008, the C.D.C. has recommended a flu shot for everyone 6 months or older.
Of the 511 children whose vaccination status was known, 84 percent had not had a flu shot. In the 2009-10 flu season, when 66 children with a known vaccination status died, 64 of them were unvaccinated.
Death often came quickly: most of the children died within a week of the appearance of symptoms, and a third of them died outside the hospital or in an emergency room.
"A lot of parents don't think of flu as being very serious, especially if their child is healthy" said the lead author, Dr. Karen K. Wong, a medical officer with the C.D.C. "But this study shows that even healthy children are at risk, and that's why it's important for every child to get vaccinated."
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