A new study adds to the evidence that low-dose aspirin, known to reduce the risk for heart disease, may also reduce the risk for pancreatic cancer.
Pancreatic cancer has a 93 percent fatality rate, and the National Cancer Institute estimates there will be about 46,000 new cases and 40,000 deaths from the disease this year.
In a five-year study, published online in Cancer Epidemiology, Biomarkers & Prevention, researchers compared aspirin use in 362 pancreatic cancer patients with 690 randomly chosen controls. Participants were asked about past and present regular use of aspirin, defined as at least once a week for three months.
After controlling for age, sex, race, smoking, diabetes and other variables, the researchers found that regular aspirin use lowered the risk for pancreatic cancer by 48 percent.
Patients who had been taking aspirin regularly for one to three years reduced their risk by 43 percent; those who had been taking it for seven to 20 years reduced risk by 56 percent.
Why aspirin would do this is unclear. "Pancreatic cancer takes 10 to 15 years to develop," said the senior author, Dr. Harvey A. Risch, of the Yale School of Public Health. "We don't know if the aspirin is preventing the formation of new tumors or helping the immune system to control them later on. Empirically it seems to do something, and at this point that's all we can say."
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